Dr. Bill Cortner (Jason Evers) has been performing experimental surgery on human guinea pigs without authorization and against the advice of his father, also a surgeon. When Bill's fiancée, Jan Compton (Virginia Leith), is decapitated in an automobile accident, he manages to keep her brain alive. He now needs to find a new body for his bride-to-be and settles on Doris Powell (Adele Lamont), a glamour model with a facial disfigurement. Jan doesn't want to continue her body-less existence and calls upon the creature hidden in the basement, one of Bill Cortner's unsuccessful experiments, to break loose.